Meeting Banner
Abstract #1574

MRI Visualization of Intratumor Release/distribution of Liposomal Drugs Triggered by Sonication/sonoporation

Enzo Terreno1, Pierangela Giustetto1, Silvia Rizzitelli1, Cinzia Boffa1, Daniela Delli Castelli1, Silvio Aime1

1Department of Chemistry and Molecular & Preclinical Imaging Centers, University of Turin, Turin, TO, Italy

This contribution deals with the use of different acoustic radiations able to trigger a non-thermal drug release from liposomes and to cause a permeabilization of the cell membranes in the lesion that facilitates the drug diffusion in the tumor mass and enables the drug to be internalized by most of the cell phenotypes of the tumor. MRI was used to provide the necessary non-invasive guide for assessing the drug distribution (as well as the tumor growth) through the use of liposomes encapsulating the clinically approved paramagnetic complex Gadoteridol.

Abstract PDF

Keywords

ability able absence achieving acoustic addition agent allow almost analogous animals apparatus application applied approved assessing black blue cancer carried caused cell cells chemistry chemotherapeutics cholesterol circulating clear clinically combination complex consensus consisted constant contrast control cycle detected development diffuse diffusion distribution drug drugs duty encapsulated encapsulating enhancement entered entrapment expected experiment exploit exposure extracellular facilitate flank focused frequency furthermore general generated graph green growth hydrophilic important indicate induce inducing injecting injection innovative inoculation intensity interestingly interstitial intracellular invasive just justified lasted lesion local localization long longer macrophages mammary mass mediated membrane membranes mice micro million minutes mixture model molar molecular mouse much necessary operating outcome paramagnetic passive pathology permeability phenotypes portion positive post potential prepared pressure previous previously primarily probe promotes pulse pulsed quenching quite radiation rapidly reduction release released remained resides short spectrometer stealth stem subcutaneous successful term therapeutic thermal thin trace transducers triggered tumor vanished variable view whereas