Meeting Banner
Abstract #1564

Assessment of Tissue Damage Using PRF-T1 Technique

Mahamadou Diakite1, Allison Payne2, Nick Todd2, Dennis L. Parker2

1Physics and Astronomy, University of Utah, Salt lake, UT, United States; 2Radiology, Utah Center of Advanced Imaging Research (UCAIR), Salt Lake City, UT, United States

One of the main reasons focused ultrasound surgery has not been used widely in the clinical setting has been the difficulty to assess the extent of biological tissue damage due to hyperthermia. Denaturation of macromolecules within the tissues is believed to be the major factor contributing to the damage of tissues upon hyperthermia. Water in biological tissues is mostly bound to macromolecules such as: protein, fibers, membranes, and ions. As a result, the values of the relaxation time (T1) of the tissue water, which are related to the translational and rotational rates of water, represent the intrinsic probes for investigating the structural changes in the tissues at high temperature. It has been also shown that methods based on the temperature dependency of the water proton resonance frequency (PRF) shift has the best ability to quantify temperature rises in soft tissues [1].

Abstract PDF

Keywords

ability absolute accurate actual altered assess bandwidth believed best biological bound built channel chicken city clinical coil computed cooling damage described despot difficulty dividing dose encouraging equation equivalent even exceeds except experimental extent fibers focused frequency future goal gradient heating hods house hybrid ideally imperfect in vivo intrinsic inversion investigate involve ions iris lake linearized macromolecules magnitude major mapping maps mated medical membranes minimize molecules necessary nick nominal occurred occurs pair parker phys pixel plot plots potential power previously probe probes profile propose protein proton pulse radiology recovery related represent requires resolution respectively rises salt scanners segmented series sets severely soft solutions sons spin steady structural surgery tech temp tempera temperature thermal threshold throughout tissue tissues train trio uniform validate variable variation versus water watt watter whether widely