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Abstract #1555

Compartmental Modelling of Regional Tumour Glucose Pharmacokinetics with Quantitative GlucoseCEST

Simon Walker-Samuel1, Rajiv Ramasawmy1, Francisco Torrealdea2, Marilena Rega2, Peter Johnson3, Vineeth Rajkumar3, Simon Richardson1, Dave Thomas2, Barbara Pedley3, Xavier Golay2, Mark F. Lythgoe1

1Centre for Advanced Biomedical Imaging, University College London, London, United Kingdom; 2Institute of Neurology, University College London, United Kingdom; 3Cancer Institute, University College London, United Kingdom

GlucoseCEST has been shown to allow the detection of exogenously administered, unlabelled glucose in tumours and we have recently extended this technique to quantify glucose concentration in vivo. In turn, this has enabled us to perform pharmacokinetic modelling of regional tumour glucose uptake. This provided estimates of the rate of glucose extravasation from blood plasma and the fractional volume accessible to glucose, using blood plasma glucose measurements from direct blood sampling. The current study is a proof-of-principle demonstration and the results open the possibility for applying more complex multi-compartmental analysis to measure regional tumour glucose metabolism.

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