Glioma Cells Overexpressing Isocitrate Dehydrogenase 1 (IDH1) Mutation Produce 2-Hydroxy Glutaric Acid Detectable in vivo

Keywords

accompanied accumulation acid additional alternatively amino among apparent appears arginine basis better blood carries carry caused cell cells choline clear coefficient color considered consistent construct containing contrast contribute control correlate correlated correlation coupling dang days detectable determine determined diffusion done early echoes enzyme established event expectations explanation expressed faster favorable flag flank frequently function gain gene glutamate good grade gradient grew growth histology hydroxy hypoxia improved in vivo injected injection injections lactate larger leading maps metabolic metabolism metabolites mice modeled mutated mutation mutations nature necrosis necrotic notice outcome outgrew oxidative parallel patients peak pixel planar plat pope post preceding precursor presence process processed produce production prognosis progression protein pseudo quantification quantify radiology reached recent reduced remains replacement reports representative represents required residue resolution responsible revealed sacrificed scale secondary serve significance significantly spectroscopy spectrum spin staining statistical studies survival system thought timothy tissue toxic transverse tumor tumors type vector viral volume volumes week wild