Meeting Banner
Abstract #1543

Combined Look-Locker Arterial Spin Labeling (ASL) and Intrinsic R2*susceptibility Response to Vascular Disruption in a Clinically Relevant Liver Metastatic Model of Colorectal Carcinoma

Sean Peter Johnson1, Rajiv Ramasawmy2, Adrienne Campbell2, Mathew Robson1, Mario Mazzantini1, Vineeth Rajkumar1, Barbara Pedley1, Mark Lythgoe2, Simon Walker-Samuel2

1Cancer Institute, UCL, London, United Kingdom; 2Centre for Advanced Biomedical Imaging, UCL, London, United Kingdom

Liver metastases are the major cause of mortality in patients with colorectal carcinoma (CRC). The vascular disrupting agent OXi4503 has been tested in phase I clinical trials of metastatic disease with R2* recommended as a biomarker of response. R2* response however may not accurately reflect response to treatment exclusively. Arterial spin labeling (ASL) is able to assess changes in tumour perfusion. We show that in a clinically relevant liver metastatic model of CRC (n=10 metastases) acquisition of combined R2* and ASL at baseline and 90min following 40mg/kg OXi4503 i.v. is more adequate at assessing response to treatment.

Abstract PDF

Keywords

able accumulation action acute administration agent agents albeit allow allowed although ambiguous animal anticancer approaches arterial assess assessment biomedical birdcage blood blower bulk cancer carcinoma caused cell cells central chap class coil combined combining complex comprehensive concentration consistent context correlated correlation culture curative currently deeper define deposits detect detection determine difficult directly displayed disrupting dissemination distinct dose echoes effective efficacy either establish evaluable excised expected fair flow free global gradient grown horizontal in vivo indicating individual initially injected insights interpretation intrinsic invasive inverse inversion king kingdom leads liver locker long look maintain mass matrix measures mechanism mechanisms median medical metastases metastasis metastatic mice minute minutes model models necrosis occurred part patients perfusion physiological plot post potential prepared presence prolong readout recently reduction relationship relevant remote reported require resection respiratory response saturation scatter serum significance slice software spacing spin suitability supplying survival susceptibility suspension system term therapeutic treatment variable vascular viable walker wash year