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Abstract #1518

Evaluation of Melanoma Xenograft Through Chemical Exchange Saturation Transfer Imaging: A Preliminary Report

Mohammad Haris1, Kavindra Nath2, Anup Singh1, Kejia Cai1, David S. Nelson2, Dennis B. Leeper3, Hari Hariharan1, Jerry D. Glickson2, Ravinder Reddy1

1Radiology, University of Pennsylvania, Philadelphia, PA, United States; 2Molecular Imaging Lab, University of Pennsylvania; 3Radiation Oncology, Thomas Jefferson University Hospitals

In this preliminary study, we explored the chemical saturation transfer effect from amino acids particularly glutamate and alanine present in the mouse model of melanoma and image them at high spatial resolution and discuss the potential significance of using this method in the management of human melanoma.

Keywords

accounts acid acids administration alanine amino among anatomical animal animals applied approximately asymmetry available biomedical bore broad cages cancer care cell cells chemical chemotherapy cocktail coil collected common concentration confirm contrast corp corrected cure curve deaths dependence derived described development diameter displays disseminated dissolved documented earlier effective evaluation eventual exchange excised exhibits explored extracted females field form free frequency frozen generated glutamate grown hill horizontal human in vivo increasingly induction inoculated inoculation inversely jerry laboratories liters long lymph macromolecules males management medicine melanoma metabolites metastatic mice million mouse nature nitrogen normalizing nude overlaid passage patients peak poor position potentially preliminary preparation prepared presence previously processing produced programmed propose protocols proton pulse radiation readout recurrence reflects report reported resolution response saturation scanner selective selectively serum significance since skin slice software specifically spectra spectral spectrum strongly studies supplemented supported surface survival term therapeutic therapy tissue tissues transfer transferred treating treatment tumor tumors water widely written