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Abstract #1517

A Comparative Study of High-Resolution Vs. Conventional Diffusion-Weighted Imaging of the Prostate at 3T

Maysam Jafar1, Sharon Giles2, Veronica Morgan2, Nandita deSouza3

1Clinical Magnetic Resonance, Institute of Cancer Research, London, Surrey, United Kingdom; 2Clinical Magnetic Resonance, Royal Marsden NHS Foundation Trust, London, United Kingdom; 3Clinical Magnetic Resonance, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, United Kingdom

In prostate cancer DWI is additionally proving useful as a predictive biomarker of disease aggressiveness but severe artefacts and low resolution can hamper accurate quantification and reduce value of the biomarker particularly where suspected lesions are <1cm2. High-resolution DWI techniques potentially improve detection of small lesions, but suffer from reduced SNR compared to conventional techniques. The purpose of this study therefore was to investigate the differences in estimated ADC values in normal prostate and prostate cancer derived from a conventional diffusion-weighted protocol vs. a high-resolution protocol.

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