Meeting Banner
Abstract #1355

Hyperpolarized Helium-3 MR Imaging of a Non-Sedated Infant: A Proof-Of-Concept Study

Talissa A. Altes1, Craig H. Meyer2, Jaime H. Mata1, Deborah Froh3, Alix Paget-Brown3, Sean Fain4, Eduard E. de Lange1, Grady Wilson Miller1, Karen Mooney1, Gordon D. Cates5, Martyn C. Botfield6, Mac Johnson6, John P. Mugler1

1Radiology, University of Virginia, Charlottesville, VA, United States; 2Boimedical Engineering, University of Virginia, Charlottesville, VA, United States; 3Pediatrics, University of Virginia, Charlottesville, VA, United States; 4Radiology, University of Wisconsin, Madison, WI, United States; 5Physics, University of Virginia, Charlottesville, VA, United States; 6Vertex Pharmaceuticals Incorporated, Cambridge, MA, United States

As a prelude to clinical studies of infants with lung disease, the purpose of this study was to develop an acquisition strategy and hyperpolarized helium-3 (HHe) gas-delivery methods to enable imaging of non-sedated infants. HHe MRI was performed in a single non-sedated, non-restrained, healthy infant, age 13 months, using a spiral-based acquisition and a simple HHe gas-delivery system. The short acquisition time of 0.12 s per slice enabled imaging of a moving infant with little motion artifact. Similar to prior results in healthy older children and young adults, the healthy infant had homogeneous ventilation on HHe MRI.

Abstract PDF

Keywords

absence achieve acquisition addition adequate administered administration adult adults agent alterations although approved around artifacts assessment attached background biologically body breath brown built central childhood children chronic clinical coil common concept considering contiguous coral cover crucial deliver delivery develop disease dose engineering ensure expected fain feasibility feel field flexible foundation freeze frequency funded gaseous general good healthy helium home homogeneously immediately important incorporated induced inert infant infants inhalation inhaled inside knowledge likely loading lung lungs medication miller minimal month motion mouth moved movement older optical otherwise particularly pediatric pediatrics phantom pharmaceuticals physics placed plastic polarizations polarized port prior procedure products proof protocol pulse pumping quality quantitative radiation radioactive radiology receive relatively removed report required resolution restrained scanner sedated sensitivity shaped short shortly slice slices spatial spiral springs started straw structure successfully sufficient superiorly supine support system throughout transmit treatments trials tuned typically utility ventilated ventilation vertex view whole wrap wrapped young