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Abstract #1285

Prediction of Histopathologic Grade of Hepatocellular Carcinoma Using Current MRI Sequences

Chansik An1, Mi-Suk Park1, Myeong-Jin Kim1, Yeo-Eun Kim1, Woo-Suk Chung1, Hyae Min Jeon2, Ki-Whang Kim1

1Diagnostic radiology, Yonsei University Health System, Seoul, Korea, Republic of; 2Pathology, Yonsei University Health System, Seoul, Korea, Republic of

The combination of signal intensities on diffusion-weighted imaging (DWI) and dynamic subtraction imaging shows a linear association with histopathologic grade of hepatocellular carcinoma (HCC). The more the positive findings shown by an HCC lesion (arterial enhancement on subtraction imaging and restricted diffusion on DWI), the higher the grade (p < .001). In predicting well-differentiated HCC, the positive predictive value is higher when the findings on DWI and subtraction imaging are considered together (100%, when a lesion shows no arterial enhancement and no restricted diffusion) than when they are considered separately (81%, no arterial enhancement; 74%, no restricted diffusion).

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Keywords

abdominal advances among apparent application approved arterial assessed automatically board carcinoma characteristics clinical clustered coefficient combination combined consent contrast control diagnostic differentiated differentiation diffusion distinguishing divided dynamic effectiveness enhanced enhancement estimating evaluated examinations features finding findings generalized grade grades health helpful histological important incidence independently individual informed institutional intensity investigate journal known lesions linear liver medical mixed model moderately park pathologic pathology patients performance poorly positive predicting prediction predictive prognostic radiologists radiology recent recurrence relationship republic restricted retrospective revealed review reviewed reviewers series solutions statistical subtraction surgically survival system table terms trend trio tumor waived