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Abstract #1183

Multi-Slice CINE Phase Contrast Pulse Wave Velocity Measurements for Characterising Aortic Cardiovascular Disease

Deirdre B. Cassidy1, Stephen J. Gandy2, 3, Patricia Martin4, R Stephen Nicholas2, 3, J Graeme Houston5, 6

1Institute of Cardiovascular Research, Dundee, Angus, United Kingdom; 2NHS Tayside Medical Physics, Ninewells Hospital, Dundee , Angus, United Kingdom; 3NHS Tayside Clinical Radiology , Ninewells Hospital, Dundee, Angus, United Kingdom; 4NHS Tayside Clinical Radiology, Ninewells Hospital, Dundee , Angus, United Kingdom; 5Institute of Cardiovascular Research, Dundee, Scotland, United Kingdom; 6NHS Tayside Clinical Radiology, Ninewells Hospital, Dundee, Angus, United Kingdom

Aortic stiffening occurs as a result of the pathophysiological contribution of age and atherosclerosis, and is associated with increased risk of cardiovascular events. This can be characterised by measurement of pulse wave velocity (PWV). PWV can be derived from phase contrast MRA using multiple aortic flow waveforms in combination with intra-arterial distance measurements. In this study, the mean PWV was found to be stable on a scan-to-scan basis in a cohort of healthy volunteers, and was found to increase significantly with age and cardiovascular disease severity i.e. the data are consistent with developing aortic stiffness.

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Keywords

able acquisition aims anatomical aorta aortic arch array arrival arterial arteries ascending atherosclerosis axial basis best bifurcation body breath burden calipers candy cane cardiac cardiovascular cine clinical cohort cohorts coil coils combination complex consistent contrast contribution cycle dataset defined derive derived descending determined developing deviation differs direct disease distance elevated encoding even events examination example explained extend fast field flash flow fold functionally gated gold greater hand healthy heart heterogeneity hospital identified immediately important institute interpolated interrogate intra invasive inverse investigate kingdom known larger length linear location marker martin matrix measure measured medical modeling objectives oblique observer occasions occurs orientation patient patients peripheral pixel plasma plot positions prescribed pressure prior procedurally proposed pulmonary pulse quantified radiology recently renal repeatability risk rogers scanned scanner segment segmented separate sessions severity shot significantly sites slice slower spine stiffness substantial successive transit trio typical upon velocity versus view volunteer volunteers wave waveform waveforms years young