Meeting Banner
Abstract #1136

Comparing the Effects of Acute Homogeneous Myocardial Infarct with Heterogenous Microinfarct on Left Ventricular Function Using MRI

Maythem Saeed1, Steven W. Hetts1, Loi Do1, Mark Wilson1

1Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, Ca, United States

The purpose was to differentiate the deleterious effects of major-vessel and micro-vessel occlusion on left ventricular function using MRI. Pigs (n=24) were divided into 3 groups: 1) control (no-infarct), 2) subjected to 90min of LAD artery occlusion/reperfusion and 3) subjected to coronary microemboli delivered into the LAD. At 3 days after coronary intervention, cine and viability images were acquired using MRI. The sizes of homogeneous infarct and microinfarct measured were 171% and 6.20.6% LV mass (P<0.01). Surprisingly, the effect on LV ejection fraction was identical in both interventional procedures, suggesting that different mechanisms govern the decline in LV function.

Abstract PDF Poster PDF

Keywords

acute additional animals artery automatic biomedical cardiac catheters chloride cine clinical comparing confirm confirmed contrast control coronary damage days decline deleterious delivering denied diastolic differentiate divided dysfunction ejection farm fraction function global govern guidance heart heterogeneous homogeneous hypothesis identical important infarct infarcts injection instability insults interval intervals intervention major mark mass matrix measure measured measures mechanisms media micro myocardial myocardium occlusion percutaneous pigs precautionary presence prevent prior procedures radial radiology remote semi session severity slice sole source stain strain studies subjected subtended suggesting summarizes surprisingly systolic table taken territory thickening threshold twenty ventricular vessel volume volumes wall