Meeting Banner
Abstract #1135

Doxorubicin Cardiotoxicity in the Rat Detected with Cardiac Function MRI and Late Gadolinium Enhancement

Neil Woodhouse1, Howard Mellor2, Jose Ulloa1, Guy Healing2, Jason Kirk2, Paul Hockings3

1PHB Imaging, AstraZeneca, Alderley Edge, Cheshire, United Kingdom; 2GSA, AstraZeneca, Alderley Edge, Cheshire, United Kingdom; 3PHB Imaging, AstraZeneca, Molndal, Gothenburg, Sweden

Doxorubicin induced cardiotoxicity was examined in two groups of male Han-Wistar rats (n = 6/group), Vehicle (0.9 % saline) and Dox (doxorubicin 1.25 mg/kg) using a retrospectively gated IntraGate FLASH multi-slice cine sequence at 4.7T. Gadopentetate was administered as an intravenous bolus to three rats per group. Significant differences in end systolic volume, stroke volume, ejection fraction, and fractional shortening were demonstrated between the Vehicle and Dox groups. There were statistically significant (p=0.001) differences in late gadolinium enhancement after gadopentetate infusion.

Abstract PDF

Keywords

acquisition additional animal animals applied atrium axis best bolus cancers cardiac cardiovascular caused chemotherapy cine circulation committee concordant conducted consistent covering damage derived detected determine development diastolic dilated dosed edge ejection enhancement ethical examine findings five flash fraction fractional function gadolinium gated healing histology immediately impair impairment indicating induced inducing infusion intravenously issue issued kingdom kirk known late local long male mass matrix measure metabolism minute minutes myocardial myocardium orientation peak period pharmacology procedures processed rats received recently recovery repetitions respiration retrospectively review saline scientific segment sensitive short shortening slice slices statistically stroke system systolic table tail toxicology treated treatment typical vehicle vein ventricle ventricular volume week weeks whole