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Abstract #1116

Two Lipid Pools Detected in the Myocardium of Rats Fed a High Fat Diet

Vijayasarathi Nagarajan1, Philip William Kuchel1, S. Sendhil Velan1

1Laboratory of Molecular Imaging, Singapore Bioimaging Consortium, Singapore, Singapore

We evaluated the myocardial fat content in rats fed with a placebo and a high fat diet. We demonstrated the presence of two lipid pools in the myocardium of the rats with obesity induced by high fat diet. The left ventricular function was significantly reduced in rats fed with high fat diet. The concentration of IMCL in myocardium may be a potential marker for early stages of diabetes.

Keywords

abdomen accumulation acids amounts analyzed animals approved assessed assessment atoms axis biological blood body bulk calorie cardiac channel chem cholesterol cine coil coils compartments consortium content control coronal correlated custom cylinders deposited described detected detection developed diabetes diet displayed distinct droplets dystrophy early ejection elongated estimation estimations evaluated evaluation excess fatty fibers fold food fraction frames free function functional generation geometry glucose heart hearts impaired improved induce induced infiltration insulin intake intensity investigated japan knowledge laboratory lipid lipids liver local localization localized long made marker mass matrix measured medium methyl methylene molecular muscle muscular myocardial myocardium obesity observation park particular patients period placebo plasma pools potential potentially presence press program pulse rats received receiving recently reduced reduction report resistance resource rial separate septum sets short significantly skeletal software spectra spectroscopy spectrum stores subjected surrounding susceptibility technology tolerance trace transverse triglyceride type unsuppressed upper ventricular water weeks whereas