Meeting Banner
Abstract #1115

In Vivo Cardiac 31P-MRS in a Mouse Model of Heart Failure

Adrianus J. Bakermans1, Bastiaan J. van Nierop1, Desiree Abdurrachim1, Klaas Nicolay1, Jeanine J. Prompers1

1Biomedical NMR, Eindhoven University of Technology, Eindhoven, Netherlands

3D Image-Selected in vivo Spectroscopy (ISIS) for non-invasive cardiac 31P-MRS was used to investigate the myocardial energy status in a thoracic aortic constriction (TAC) mouse model of heart failure. By maintaining a constant TR, signal contamination from tissue surrounding the heart was minimized. Left ventricular function and morphology were assessed using cine MRI.

Abstract PDF Poster PDF

Keywords

addition anesthetized animal arising assessment bandwidth biomedical birdcage blood body built cardiac chest cine coil combined complete constant contamination contribution control controls correct corrected correction cubic custom cycles decreased demand described designs determine diastolic disease distinguished done dummy enable enclose energy equipped establish excitation excitations extensively extent failure foundation fresh functional gated gates gating healthy heart homeostasis horizontal hours imbalance importance importantly in vivo indicating inorganic invasive investigate linear localization made magnetization maintain maintaining manually marginal measured mechanisms medicine metabolites mice minimized model models molecular mouse myocardial myocardium normalized obscured offers opportunity partial phosphate phosphorus positioned powerful preparation previously progression prone proton pulse pulses quadrature rapid recovery reduced resonator respiratory revealed saturation scheme secant selected served session setup seven shimming signs since spectra spectroscopy spectrum status steady support supported surface surgery system table therapeutic thoracic tissue tolerated took translational transmission triggered triggering underlying unique unlocalized valuable ventricular vital volume weeks whereas widely wild