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Abstract #1075

Probabilistic Atlas of the C57BL/6J Mouse Cerebellum

Jeremy F P Ullmann1, Andrew L. Janke1, Charles Watson2, Nyoman D. Kurniawan1, George Paxinos3, Marianne D. Keller1, Zhengyi Yang1, Kay Richards4, Gary F. Egan5, Steve Petrou4, 6, Graham J. Galloway1, David C. Reutens1

1Centre for Advanced Imaging, University of Queensland, Brisbane, QLD, Australia; 2Curtin University, Perth, WA, Australia; 3Prince of Wales Medical Research Institute, Sydney, NSW, Australia; 4Florey Neuroscience Institute, Parkville, VIC, Australia; 5Monash University, Clayton, VIC, Australia; 6Centre for Neuroscience, University of Melbourne, Parkville, VIC, Australia

In this study we developed 1) a detailed protocol for segmenting over 35 structures in the ex vivo C57BL/6J cerebellum on high-resolution MR images and 2) a probabilistic atlas of the C57BL/6J cerebellum.

Keywords

academic achieved acquisition addition adult anatomical animals applied appropriate architecture atlas atlases averaging axial back basis biological boundary brain brains capture cerebellum cerebral coil components computational confidence consequence consortium containing control coordinates coordinating cortex create created creates creation critical days delineated delineations detailed details developed digital dimensional disease diseased disorders double enable excitations extracted final fissures fitting fixed franklin future generated gradient graham grid hierarchical human in vivo input institute inter international isotropic label lack landmarks linear location made mapping maps mechanisms medical mice micro microscopy model models motor mouse movement namely native necessary neurological noise nonlinear nonlinearly paper partitioned pediatric perfused permits placed press prince probabilistic produce protocol reconstruction reconstructions recursive registration reproducible resolution scheme segmentation segmenting sets shortcoming smoothed space spectral spring standardized statistical step strategy structural structure structures studies subject sufficient surface symmetric system traced trans transform transformation transformed unbiased underlying validated variability vector visage visible volumes voluntary wales yang