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Abstract #1074

Microstructural Evolution of White Matter from Macaque to Human Brain with in vivo DTI

Hao Huang1, 2, Tina Jeon1, Takashi Yoshioka3, Virendra Mishra1, Austin Chen3, Steven Hsiao3, Peter C. van Zijl4, 5, Susumu Mori4, 5

1Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States; 2Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, United States; 3Mind and Brain Institute, Johns Hopkins University, Baltimore, MD, United States; 4Department of Radiology, Johns Hopkins University, Baltimore, MD, United States; 5F.M.Kirby Research Center, Kennedy Krieger Institute, Baltimore, MD, United States

Comparison of gray matter volumes with MRI has provided us with insight on the anatomical evolution from non-human primates (M. mulatta) to humans. High resolution DTI was acquired from 10 in vivo macaques and 15 normal young human adults. DTI-tractography has been applied to trace 14 common major tracts in both macaque and human brains. Fractional anisotropy, mean diffusion, axial and radial diffusivity of these tracts were measured. These metrics characterizing the tract-level microstructures quantitatively were compared between macaque and human brain. Increased myelination of prefrontal, limbic white matter and left cortico-spinal tract was found from macaque to human brain.

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Keywords

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