Meeting Banner
Abstract #1016

Evaluation of USPIO Uptake to Assess the Risk of Future Cerebrovascular & Cardiovascular Events: Long-Term Follow-Up of the ATHEROMA Trial

Andrew J. Patterson1, Andrew J. Degnan1, Martin J. Graves1, Tjun Y. Tang2, Jonathan H. Gillard1

1Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, England, United Kingdom; 2Department of Vascular Surgery, Cambridge University Hospitals NHS Foundation Trust, Cambridge, England, United Kingdom

A long-term follow-up study assess if USPIO intra-plaque uptake is predictive of subsequent cerebrovascular and cardiovascular events. Sixty-two patients were followed for a median of 4 years in which 17 patients had subsequent events. Survival regression models are applied to assess if signal intensity change following USPIO is predictive of events.

Keywords

ability activity agents alternatively arms array arrow artery assess assessed association attacks basis capable cardiovascular carotid carotids censorship circulation clinical cohort cohorts coil contrast control curves defined demographic depicts detect diluted divide dose efficacy either elapsed electronic england enhanced enhancement establish establishing evaluation event events examination example experience experienced exploring extent fatal focal foundation gaps general hazard horizontal hospitals illustrated inadequately included indicated infarctions inflammation infusion initial intensity inter interaction inversion kingdom larger long loss lumen machine macrophage males martin median midpoint minutes model modeling models morbidity mortality muscle myocardial normalization notes outcome patients percentage period placed plaque population positive post practitioner predict predictive prescribed proportional psychiatry quadrant quadrants radiology randomly rational records recruited reduction regression related report reported response retrospectively risk sample separate slice slices slow sought spiral strokes studies subsequent survival tang term therapy threshold trajectory transient treatment trial trials trust ultimately uptake utility variable vascular weeks whole years