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Abstract #1001

Quantitative Magnetization Transfer Imaging in Normal Aging, Amnesic MCI & Alzheimers Disease

Giovanni Giulietti1, Marco Bozzali1, Laura Serra1, Barbara Spano'1, Barbara Basile1, Roberta Perri2, Camillo Marra3, Carlo Caltagirone2, 4, Mara Cercignani5

1Neuroimaging Laboratory, Foundation IRCCS Santa Lucia, Rome, Italy; 2Department of Clinical and Behavioural Neurology, Foundation IRCCS Santa Lucia, Rome, Italy; 3Institute of Neurology, Universit Cattolica, Rome, Italy; 4Department of Neuroscience, University of Rome Tor Vergata, Rome, Italy; 5Clinical Imaging Sciences Centre, Brighton and Sussex Medical School, Brighton, United Kingdom

This study evaluate the sensitivity of quantitative magnetization transfer (qMT) imaging to the subtle tissue changes expected in subjects with amnestic Mild Cognitive Impairment (aMCI), a condition considered as a prodromal stage of AD. To this purpose, a multimodal image analysis was used to take into account grey matter (GM) atrophy. The results confirm that among qMT parameters, RM0B is the most sensitive to AD pathology. Additionally, this parameter appears to be already reduced in some GM areas of patients with aMCI. These changes are likely to precede the appearance of macroscopic atrophy.

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Keywords

abnormalities according account adjusting aging although amnesic among amplitude anterior applied arch assessing atrophic atrophy attempts basis bilaterally biological bound brain clinical cluster cognitive combinations comparing compute condition confirm considered consistent controls corrected cortex described determinant diagnosed dimensional disease domain driven early equilibrium every examination exchange extension extensively fact find findings fitted fixed flash forward foundation frequency gender govern healthy impairment included institute insular interpretations kernel kingdom known laboratory largest local located longitudinal loss macromolecular macromolecules magnetization mapping maps matrix medical metabolic mild modal model modulated multiplication neurology normalization normalized nuisance occipital offset parametric particular pathology patients pattern permits physical pipeline pole pool pools posterior previous probable procedure process processed properties protons quantify quantitative recently recruited reduced reductions reflect regressors reported respectively school sensitivity series session smoothed space stage statistical subject subjects subtle suggests take temporal thalamus thick tissue transfer transform transformation transition underwent variable various volume warped widespread years yield