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Abstract #0996

Altered Neuronal & Astroglial Metabolism in APP-PS1 Mouse Model of Alzheimers Disease

Vivek Tiwari1, Pandichelvam Veeraiah1, Anant Bahadur Patel1

1NMR Microimaging and Spectroscopy, Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India

Alzheimer's disease is associated with dysfunction and deficit of neurotransmitters and synapses. Neurochemicals and cerebral metabolism was studied in 12 month old APP-PS1 mouse model of Alzheimer's disease. Level of Glutamate and NAA was found to be lower while inositol was significantly higher in APP-PS1 mouse. Glucose oxidation by glutamatergic and GABAergic neurons, and neurotransmitter cycling was found to be impaired significantly in APP-PS1 mice. In contrast, astroglial metabolism was found to be higher in APP-PS1 mice at cognitive impaired stage.

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