Regional Glutamate Alterations in 11-Month-Old Tg2576 Mouse Model of Alzheimer's Disease Detected by in vivo 1H Magnetic Resonance Spectroscopy at 9.4 T

Keywords

acquisition aging already alterations although anesthetized animals appear applied assigned attempted bars basis begin beginning better biology birdcage bounds brain breeders characterized chemistry classified clearly cognitive coil commonly concentrations console constantly correlate correlated correlation correlations cortex decline decrease dependent deposition described detected disease early equipped error etiology evident except excitatory expressed fayed formation frequency function functions genders glutamate gradients gray help hypothesized impairment important in vivo initially inside institute internal investigate involvement kindly known learning load loss matched mates measured medical memory metabolites mice might model models monitor monitored monitoring month months mouse needed neurology neurotransmitter none observe open outlined oxygen partly pharmacological pink plaque plaques plays positioned possibility previous previously probe procedure profile progressive proton providing quantification quantified radiology rapid rather recent regional reliably reported role science severity short significance since spectroscopic spectroscopy speculate statistical strengths student studies suggest system systems tailed term thalamus thank till trend ultrahigh unsuppressed useful vertical wide