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Abstract #0964

Neural Substrate of Morphine Withdrawal Symptoms in Rat Revealed by Manganese-Enhanced Magnetic Resonance Imaging

Haichen Niu1, Dai Shan1, Shaorui Li1, Xuxia Wang1, Fuchun Lin1, Hao Lei1

1State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, China

Chronic morphine exposure induces dependence. Abstinence from the drug causes withdrawal symptoms. Many previous studies have investigated the neural substrate of morphine withdrawal symptoms. In this study, we employed manganese-enhanced MRI (MEMRI) technique to map accumlative brain activities in morphine-treated rat in a 24-hour period during spontaneous withdrawal.

Keywords

abstinence academy accumulative activation activations activities activity amount anesthesia animals anterior artifacts atomic awake behaviors bouts brain causes central china chosen chronic circuitry cold color concluded consecutive control core corrected cortex creation dataset days deject dependence dorsal dose doses drill drug employed enhanced enhancement erection escalating example experimental exposure face finally flash foundation freely grants granular grid groom hour hypothalamic independent induced induces inhibition initial injected injection institute intensity investigate investigated isotropic kernel laboratory last lateral male manganese many materials mathematics matrix measure ministry molecular morphine motor moving natural neural neuronal normalized nucleus overall paradigm people period physics pixels posterior precipitated previous protocols pure rats recorded registered reported representative republic rest revealed rewarding saline samples scanner science sciences secondary session shell shock smoothed solution spontaneous stripped studies subfield subjected subregion substrate substrates suggested supported symptoms tailed technology teeth template tissues treated tremble verified verify warm wash weighing whole wise withdrawal withdrawals