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Abstract #0936

Quantitative Examination of Negative Spaces in a Crouzon/Pfeiffer Mouse Model at Birth Using Multimodal Imaging

Susan M. Motch1, Thomas Neuberger2, 3, Neus Martnez-Abadas1, Talia L. Pankratz1, Yingli Wang4, Ethylin W. Jabs4, Timothy M. Ryan1, Joan T. Richtsmeier1

1Department of Anthropology, The Pennsylvania State University, University Park, PA, United States; 2Huck Institute of the Life Sciences, The Pennsylvania State University, University Park, PA, United States; 3Department of Bioengineering, The Pennsylvania State University, University Park, PA, United States; 4Department of Genetics and Genomic Sciences, Mt. Sinai School of Medicine, New York, NY, United States

We used MR and CT images of littermates of the Fgfr2cC342Y/+ mouse model for Crouzon/Pfeiffer syndromes, to investigate the global and regional impact of this mutation on the developing negative spaces of the head and skull at P0. Volumetric measurement using MR images indicated restriction of the nasopharynx of Fgfr2cC342Y/+ mice (n=8) compared to non-mutant littermates (n=11), but no difference in cochlear and semicircular canal volume. Global and regional (cranial vault, cranial base, facial skeleton) differences in skull morphology were observed using configurations of 3D landmark coordinates measured on CT isosurfaces in Fgfr2cC342Y/+ mice (n=28) relative to non-mutant littermates (n=31).

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Keywords

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