Meeting Banner
Abstract #0931

Study of PH-Sensitive Magnetization Transfer Imaging in Hyperacute Brain Infarction Using a Clinical 1.5 Tesla Scanner

Taifeng Lin1, Maobin Wei1, Zhiwei Shen1, Gang Xiao1, Renhua Wu1, Phillip Zhe Sun2

1Shantou University Medical College, Shantou, Guangdong, China; 2Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States

pH-sensitive magnetization transfer (MT) imaging can reflect the alteration in metabolism. Using this technology to image ischemic brain may make an early detection and prediction of ischemic penumbra. Twelve male cats underwent permanent MCAO, and ischemic evolution was observed at a clinical 1.5 T scanner through clinical T1WI, T2WI, DWI and MT-imaging. We found that in 5 of 12 animals hypointensity in occlusion side was displayed on MT-imaging, when there was no any alteration on the clinical images yet. In other 7 of 12 animals, we could observe the intensity alterations in DWI and MT-imaging at the same time. We also found that pH-sensitive MT-imaging was sensitive to detect infarction prior to current clinical sequences and might be able to predict ischemic penumbra.

Abstract PDF

Keywords

acid addition alteration altered animals applied approximate approximates artery biomedical blood blue boundary brain cats cerebral channel china clinical closely coil college color comparing corresponded dark darkest detect detection diagnostic displayed disturbance early eight encoding even frequency gang good head helps hemisphere hour hours identify included infarct infarction influence intensity intracellular lacks lesion lesions lightest lobe magnetization make male materials medical metabolism middle neck nervous observe occlusion offset optimum oxygen parietal part patients penumbra people prediction prepared protocols radiology readout reception reflect republic scanned scanner select sensitive sensitivity separately sharper side sides slice spacing spin stage stroke technology temporal tissue transfer transmission treatment twelve visible wider