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Abstract #0930

Characterisation of Rat MAM Model of Schizophrenia by in vivo Structural & Pharmacological MRI

Diana Cash1, Winfred Chege1, Michel SB Mesquita1, Nadia N. Malik2, Mark D. Tricklebank2, Michael J. O'Neill2, Steven CR Williams1

1Neuroimaging, King's College London, London, United Kingdom; 2Eli Lilly and Co., United Kingdom

 

Keywords

abnormalities activation activity administered aged agent amphetamine antagonist attenuate attenuated blood blue body bold brain brains cash chambers circuits cognitive cohort college conducted confirm consistent continuously cortex cortical cortices courses dams decreases delineate derived described displayed displaying distance dopamine dorsal earlier early efficacy encompassing enhanced enlarged even exemplified exhibit experiment final flow function functional green habituation hypersensitive imbalance in vivo indicative induced injection input isotropic king kingdom linked locomotor long made manually maps mark masked measure measures minute minutes model months offspring overall overlaid parietal particularly pattern persist pharmacological post pregnant previously prior probably processed psych putative rats realigned received recording recordings reduced reflect remained repeated reported resolution response responses reveal revealed saline scanner schizophrenia serial several sham shams shrinkage significantly slices smaller smoothed software statistically structural systems template term thalamus therapies threshold throughout transmitter treated treatment trend trust typical underlying undertaken vehicle ventricles versa vice visual volume volumes whereas widespread yellow younger