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Abstract #0919

Trans-Blood-Brain Barrier Drug Delivery Via Ultrasound & Microbubbles for Neurodegenerative Diseaseses

Michael Valdez1, Eriko Yoshimaru1, Pier Ingram2, John Totenhagen1, Aaron Forbes3, Stephen Moore1, Paul Helquist3, Terry Matsunaga2, Russel Witte2, Lars Furenlid, 24, Zhonglin Liu2, Robert Erickson5, 6, Theodore Trouard1, 2

1Biomedical Engineering, University of Arizona, Tucson, AZ, United States; 2Radiology, University of Arizona, Tucson, AZ, United States; 3Chemistry, University of Notre Dame; 4Optical Sciences, University of Arizona, Tucson, AZ, United States; 5Pediatrics, University of Arizona, Tucson, AZ, United States; 6Molecular and Cellular Biology, University of Arizona, Tucson, AZ, United States

Treatment of neurological disorders is often hampered by the inability of drugs to get across the blood-brain barrier (BBB). Novel techniques have been developed that use ultrasound in combination with microbubble contrast agents to reversibly open up the BBB for drug delivery. We have combined these techniques with high-resolution -ray imaging to directly image the crossing of radiolabeled beta-cyclodextrin, a promising new therapy for Niemann-Pick type C disease, into the brains of mice in vivo.

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Keywords

administration agents allowed allowing allows apparatus applied array attached barrier bars beta biology biomedical birdcage bite blood bolus brain brains built carried cellular channel chemistry cholesterol coil combination combine common comprehensively contrast control cradle cross custom dame deficits delivered delivery developed directed directly disease disorders drug drugs duty engineering enhancement enter errors evaluate every except excitation experimental extracted extremely flow foundational function gadolinium generated goal greater hours immediately impact inability indicate initiated injected injection intensity just magnet maps mediated medical mice mind minute minutes model models molecular mouse negative neurological novel obvious open opening optical original passage pause peak pediatrics percent photograph pick position positioning post pressure printer prior procedure promising radioactivity radiology rapid readily receive received reception remained rendering repeated residual resolution returned reversibly secured several solution studies suppl system tail temporarily terry therapeutic tissue towards trans transducer translation treatment twofold ultrasound underwent useful utilized vein verified visible width years