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Abstract #0879

Brain Development & Effects of Chronic Fetal Hypoxia in Neonatal Guinea Pigs: DTI, T2 & Volumetric MRI at 9.4T

Jieun Kim1, In-Young Choi1, 2, Yafeng Dong3, Wen-Tung Wang4, William Brooks1, Carl Weiner3, Phil Lee1, 5

1Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, KS, United States; 2Neurology, University of Kansas Medical Center, Kansas City, KS, United States; 3Department of Obstetrics and Gynecology, University of Kansas Medical Center, Kansas City, KS, United States; 4Center for Neuroscience and Regenerative Medicine, NIH/USUHS, Baltimore, MD, United States; 5Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, United States

Chronic hypoxia during the gestation period (hypoxemia) can cause the neuronal death and slow neural migration in the developmental brain. This study aims to investigate the effects of chronic fetal hypoxia on postnatal guinea pigs in the developing brain longitudinally using in vivo MRI of T2 maps, DTI and volume measurements. DTI and T2 measurements suggest delayed axonal myelination and tissue maturation during development of neonatal guinea pigs that experienced chronic fetal hypoxia.

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Keywords

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