Meeting Banner
Abstract #0878

DTI Investigation of Short-Term Plasticity in Amygdala & Hippocampus Induced by Fear Conditioning

Abby Y. Ding1, 2, Qi Li3, 4, Iris Y. Zhou1, 2, Grainne M. McAlonan3, 4, Ed X. Wu1, 2

1Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong SAR, China; 2Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong SAR, China; 3Department of Psychiatry, The University of Hong Kong, Hong Kong SAR, China; 4Centre for Reproduction Growth and Development , The University of Hong Kong, Hong Kong SAR, China

Fear conditioning (FC) is widely used to study the neural basis of learning and memory. The pivotal role of amygdala and hippocampus in memory formation and consolidation is well documented. in vivo DTI was employed in this study, voxel-based significant and distinct FA changes were found in amygdala and hippocampus, suggesting possible microstructural up-regulating in amygdala versus down-regulating in hippocampus 1 hour post-FC. Such changes reverted at 24 hr post-FC in various DTI indices. Our results indicated that DTI could be sensitive to probe short-term plasticity, and may provide insights for the accompanied brain plasticity network after FC

Abstract PDF

Keywords

accompanied acquisition additional aims alcohol allowed although among animal animals anxiety arise artifacts assess associative axial basis behavioral biological brain branching bulk bull cell central chamber chambers china cleaned clicker collected conditioned conditioning confirmed considerable consistency consistent consolidation contrary control coronal correspond cued days decrease decreased detected diffusion diffusivity directly distinctly documented dots dynamically emerging evidences examined expression fear formation growth hand histology hong illustrates in vivo index indicated individual induced insights invasive iris laboratory layer learn learning maps marker memories memory mice monitoring mostly mouse nature neural normalization nucleus occurred paired pairing paradigm paralleled people placed plasticity polymorph positive post posterior powerful presentation presentations previous probing procedures processes processing projected protocol protocols psychiatry radial regulated regulation remain represent reproduction republic rest reverse sample scale scanned scanner selected sham shock short shortly shot significantly slice statistical stimulus structural studies synapses task term threshold tissues tool trained training trial underlying underwent various versus widely