Meeting Banner
Abstract #0850

Correlation of MRI-OEF & PET-OEF Neuroimaging Data for Study of Hypoxia in Brain Tumors

Parinaz Massoumzadeh1, Hongyu An2, Joshua Shimony1, Dhanashree Rajderkar1, Anna Carlson1, Jon Christensen1, Zhang Xiaodong2, Daniel Marcus1, Keith Rich3, Tammie Benzinger1

1Mallinckrodt Institute of Radiology, Washington University in St. Louis, School of Medicine, St. Louis, MO, United States; 2Department of Radiology, University of North Carolina, School of Medicine, Chapel Hill, NC, United States; 3Neurosurgery, Washington University in St. Louis, School of Medicine, St. Louis, MO, United States

Cerebral hypoxia can potentially impact treatment outcome and brain tumor patient survival. Preliminary results of a non-contrast MR procedure for measuring brain and brain tumoral OEF are presented and compared with the results obtain using the noninvasive 15O-PET technique. Although good correlation between OEF-MR and OEF-PET is obtained, and both method show abnormality in tumor area, some discrepancy between the two methods is observed which requires further investigation.

Keywords

abnormality acquisition adjacent advanced altered although anatomic asked available biograph blood bold brain breast carefully cell cerebral chapel clinical coil collected combination complete concurrent consumption contains contra contrast correlation correlations currently default defined dimensional directly discrepancy drawn dynamic edema either element eliminating emission employed enhanced enhancing expression extraction flow fraction frequency gene good gradient head hill human hypoxia imbalance impact in vivo included indicate inhale injected injection insight institute investigation involved lateral lesions little mapping measure measured measuring medicine metastatic monoxide mutation need neurosurgery noninvasive north offer ongoing outcome oxygen patient patients physiology plots populations positron post potential potentially preliminary primary prior procedure procedures processed project promising protocol quantitative radiation radioactive radiology receive recruited regional registered requiring resolution respectively response rich sample saturation scanner scanning school selected sensitivity shimming similarly spacing spin steam subjects supply survival susceptibility system therapy tissue tomography treatment tremendous tumor tumors undergo undergone underlying upon validated volume water white