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Abstract #0846

Contrast Leakage in High Grade Glioma Measured with Independent Component Analysis of Dynamic Susceptibility Contrast MRI

Peter S. LaViolette1, Alex D. Cohen2, Kathleen M. Schmainda, 12

1Radiology, Medical College of Wisconsin, Milwaukee, WI, United States; 2Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States

This study measures the difference between the two separate contrast agent boluses in patients with high-grade glioma using regions of interest (ROIs) defined by a novel unbiased independent component analysis (ICA) approach.

Keywords

acquisition activation addition administered agent align alleviates apparent applied arterial arteries aspects automatic automatically biophysics bolus boluses brain causing cerebral characteristics chart clear clearly clinical cognitive collected college component components concentration confounds considered consisted consuming contrast correction create curve curves debate defined delineate delineates demonstrating derived determine diminish dose doses drop efficacy enhancing enrolled equivalents error extracted field functional funding gadolinium gathered grade grades gradient greater hypothesis implemented independent initial largest leakage library load manual maps matrix measure measured measures medical melodic middle mixture model modeled motion need needed nonexistent novel null patient patients peak perfusion peter planar plotted prescription prior probabilistic processed processing produced prone radiology recovery reliability reliable remains removal representative represents residual responding rise scanner separate separated separates separation settings shot significantly skip slice smith statistically still subjective subtracting suppression susceptibility task temporally thresholded tissue tool trans tumor tumors type types typically unbiased veins venous view visible volume