2-Hydroxyglutarate in Gliomas with IDH Gene Mutation Using High Resolution 1H-NMR Spectroscopy of Tissue Extracts

Keywords

absolute accepted acid acquisition addition amplitude assign assignments authentic available biopsies broadband care cause chemical citric clinical complex concentration concentrations confirm consistent contained contributing cycle dang decrease delay detect detected deuterium difficult dimensional disease dispersion easily elevated enriched enzyme equation examined extracts finding fitting function gauss gene give glucose grade grades health help identified in vivo infusing infusion investigate mass measure measured medical metabolism metabolite metabolites methylene molecule moles multiplets mutant mutated mutation mutations nature negative north nuclei observe overlapped overlaying oxide parsons partially patients positive presence previous probe production prognosis pulse receiving redissolved reflects repetition reported represent representative resection resolution resolved sample samples science secondary serve seven solutions somatic southwestern spectra spectral spectrometer spectroscopy status stratification supports surgical sweep system taken taking terms tissue tissues transients tumors type vitro width wild