Meeting Banner
Abstract #0790

Correlation Between MEG Gamma Phase Locking and 1H-MRS Determined Temporal Lobe GABA in Subjects with Schizophrenia and Normal Controls

Mark S. Brown1, Peter Teale2, Dan Collins2, Bryce Pasko2, Debra Singel3, Don C. Rojas2, Martin Reite2

1Radiology, University of Colorado Denver, Aurora, CO, United States; 2Psychiatry, University of Colorado Denver, Aurora, CO, United States; 3Brain Imaging Center, University of Colorado Denver, Aurora, CO, United States

Magnetoencephalography (MEG) recordings of neural oscillations of the gamma band (~40 Hz) phase locking factor (PLF) yield a number that measures how well the response coincides with the stimulus in time. Schizophrenic subjects show impaired tracking ability compared to controls. We have measured the GABA levels in the temporal lobe (auditory cortex) of schizophrenics using J-edited 1H MRS and correlated them with the PLF. Schizophrenics show a negative correlation with PLF compared to the positive correlation exhibited by controls. The results suggest that the impairment is not due to lower levels of GABA, but rather impaired utilization by the schizophrenics.

Abstract PDF

Keywords

abstract activity added adult amplitude analytic annual auditory aurora authors band black brain briefly brown capability cell coincides completely contents control controls correlation correlations cortex density described details determined differing divided duration earpieces edit editing equivalence every evoked expanded fields foam gamma good grant gray head health hemisphere highly impaired index inhibitory insert interestingly last lead lewis lobe lobes locking males mark marked martin measured measures meeting mega modulated monaural nature near necessarily negative neural numerically official oscillations overall peak perhaps peter physical plots position positive preliminary presentation press previous previously proceedings produce produced psychiatry pyramidal radiology random rather recorded recording recordings reduced reduction repeated reported represent response responses responsibility reviews schizophrenia schizophrenic schizophrenics short side silent sine sole spectra spectrum spine stimuli stimulus strong studies subjects subtraction suggest suggested supine support supported sweet synchronized temporal transient trials utilization versus video views volume watched waves whole year yield zero