Meeting Banner
Abstract #0712

In Vivo GABA T2 Determination with J-Refocused Echo Time Extension at 7T

MAGNA25Anna Andreychenko1, Dennis W.J. Klomp1, Robin A. de Graaf2, Peter R. Luijten1, Vincent O. Boer1

1Imaging Division, UMC Utrecht, Utrecht, Netherlands; 2Departments of Diagnostic Radiology and Biomedical Engineering, Yale University, Yale, United States

A method to measure T2 relaxation times when using spectral editing techniques is proposed. A spectrally selective refocusing pulse was incorporated into MEGA-sLASER editing technique to refocus J-modulation of the edited signal at different echo times. In this way the echo time can be arbitrary extended while preserving the shape of the edited signal. The efficiency of the method was demonstrated for in vivo creatine and GABA T2 measurements at 7T.

Abstract PDF Presentation Video

Keywords

absent absolute account acid acquisitions added addition additional agreement allows amplitudes applied arbitrary array bandwidth biomedical black bootstrapping bounds brain challenging channel chemical close coil combination combined concentrated concentration corrected correction cortex coupled coupling curve curves dataset decay dense depending detect determination determined diagnostic division doublet duration easy edited editing efficiency efficiently eliminate enabling engineering error even every excluding exponential extend extended extension facilitates fitted fitting fixed flexible frequency full graphs head healthy hence human illustrated in vivo individually influence insets intensity interfaced internal least limits literature long macromolecules measure measured mega metabolites modulated modulation must natl near need normalized note optimized outside overlapping peter plotted preserving previously propose proposed pulse quantification radiology receiver refocus refocused refocusing relatively reported retrospectively robin sampling scanner selective sensitivity shape shapes singlet spectra spectral spin splitting square straightforward strongly subject subjects subtracted system taken target together trans transmit unambiguously uncoupled usually visual volume volunteers wild