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Abstract #0616

Multimodal Spinal Cord MRI for Temporal Characterization of Posttraumatic Vascular, Metabolic and Structural Events in a Mouse Model of Spinal Cord Injury.

Virginie Callot1, Mohamed Tachrount1, Jrme Laurin2, Andr Maus de Paula3, Tanguy Marqueste2, Patrick Decherchi2, Patrick J. Cozzone1, Guillaume Duhamel1

1CRMBM, CNRS, Aix-Marseille Univ, Marseille, France; 2ISM, CNRS, Aix-Marseille Univ, Marseille, France; 3Service dAnatomie Pathologique, Hpital de la Timone, AP-HM, Marseille, France

In this work, a multimodal MRI approach, including diffusion tensor imaging, perfusion imaging and MR spectroscopy, was applied in a follow-up study dedicated to the characterization of posttraumatic events consecutive to moderate and severe mouse spinal cord contusion injury.

Keywords

able acute adequate allowed alterations altered analyses anesthetized animals anisotropy apparent applied arterial assess attributed basal better canonical cascade caudal cellular characterization characterizing choline coefficient coil confirmed consecutive context controls contusion cord correlated cytotoxic days debris decrease decreased defects demand description developed diagrams diffusion discriminant disruption distinguished dwell edema events examined extent fair features fiber finally five flow force fore fractional functional give grasping gray hall help histochemistry histology human identification identify impact impactor impairment impairments in vivo incomplete induced infinite influence injury labeling lateral lesion lesions limb maps markers measured metabolic mice model models moderate modified moreover mouse neuronal normalized optimal optimized overreached paralysis pathogenesis pathological pattern perfusion permit physiologic post process progression properties proposed rapid receiver relevant repair representation represented response rodent schematically sensitivity service severe side slices software specificity spectroscopic spin spinal structural submitted suffered suggesting synthetic system temporal tensor tissue transmitter univ vapor vascular weeks whereas white widespread windows