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Abstract #0615

Cerebrospinal Fluid (CSF) Flow Suppressed Spinal Cord Functional MRI Using Multi-Slice DANTE-EPI

MAGNA25Linqing Li1, Yazhuo Kong1, Jonathan Brooks1, Karla Miller1, Peter Jezzard1

1FMRIB, Clinical Neurology Department, University of Oxford, Oxford, United Kingdom

DANTE pulse trains (a rapid series of low flip angle RF pulses interspersed with gradients) can attenuate moving CSF signal and preserve most of the static tissue signal. Here, we propose a method that employs DANTE preparation for CSF flow suppression in multi-slice spinal cord fMRI. Compared to a conventional EPI spinal cord sequence, the temporal variance within the spinal cord was decreased. Improved activation patterns were observed using a block-design finger tapping task.

Keywords

acquisition activation activity adapted although anatomical application applied assessed attenuated attenuation axial background bandwidth bellows biomedical block blocks bold bright brooks cardiac caused cervical channel clinical coil contamination contrast cord corrected courses decreased decreasing delay design diffuse dominant effectively either employing encoding equal except false feat filtered finger flirt flow fluid frequency functional funding gradients hand healthy identical indicating individual instabilities integration inter interleaved known largely located location longitudinal magnetization maps mask miller mixed model module motion motor movement neck neurology neurons nine noise novel ongoing outperformed oxford part partial partially particular particularly patterns performance physiological power preparation preserved previously primarily primary problems propose proposed protocols pulsations pulse pulses quality rapid readout receiver reduced regressors related reported represents reserved resolution rest resting revision runs scanner series seven slab slice slices smoothed source spectra spinal spins static stimuli studies subjects subsequently suppressed suppression surrounding tapping task temporal thank tissue uncorrected variance zero