Meeting Banner
Abstract #0553

Biologically-Guided Radiation Treatment of the Prostate Using 1H-MRSI

Niranjan Venugopal1, 2, Lawrence Ryner3, Keith Nakonechny2, Boyd McCurdy2

1Physics and Astronomy, University of Manitoba, Winnipeg, Manitoba, Canada; 2Medical Physics, CancerCare Manitoba, Winnipeg, Manitoba, Canada; 3National Research Council Institute for Biodiagnostics

Using intensity modulated radiation therapy (IMRT), we can now accurately deliver radiation doses to dominant intraprostatic lesions as identified by 1H-MRSI. Using a modified tumour control probability (TCP) formalism, which includes the 1H-MRSI data, we determine the optimal dose distribution that would enable equivalent control of the prostate cancer by escalating the dose to the localized DIL. The TCP and normal tissue complication probability (NTCP) for both plans were calculated, and compared. The result of this study indicates that optimizing the dose to the prostate according to 1H-MRSI information is possible, and that it can be used to logically derive new prescription doses leading to improved TCP.

Keywords

according accounting accuracy accurate achieve achieved actual acute additional adequate aggressiveness appropriate array assuming assumption astronomy axial basis better biological biologically calculation cancer cell characterizes choline citrate clearly clinical coil combination combined comparable complication confirming conformity control corrected council defining deformable deformations delivering density determine determined developed directly disease distribution dominant dose doses early enable entire escalating escalation estimating examine exceeding exist feasibility formula general gland goal histograms hypo hypoxia identified identifying imported improves include inclusion incorporate incorporates institute intense known leading lesion like ling localized logically matrix medical metabolic metrics minutes modeling modify national needed nominal novel optimized optimizing overdosing painting peripheral phys physics plan planning plans predicted prescribed prescription presence press probability profit propose prostate protocol radiation registration required retrospective scaled scanned scanner scenario seven slightly spatial spectroscopic spread staying subjects target therapy throughout tight tissue tissues tolerances torso treatment trial uniform uniformly utility variation variations volume volumes zone