Meeting Banner
Abstract #0545

MR T1ρ Imaging on Human Prostate Cancer

Xiang He1, Serter Gumus1, Ayaz Aghayev1, Jie Zheng2, Kyongtae Ty Bae1

1Department of Radiology, University of Pittsburgh, Pittsburgh, PA, United States; 2Mallinckrodt Institute of Radiology, Washington University in St Louis, St Louis, MO, United States

In this study, we developed and applied a T1ρ sequence to image the prostate in healthy normal controls and patients. Our results demonstrated that T1ρ quantification is feasible in 3T MR scanner without the utilization of an endorectal coil. While peripheral zone T2 and T1ρ maps were often homogenous in healthy control subjects, large regional heterogeneity can been also observed due to the variations on granular structure. The discrepancy of T2 and T1ρ behavior in prostate peripheral lesion area in patients is likely due to increased cellular content. This may provide additional information to improve the diagnosis of prostate cancer.

Keywords

abnormally accuracy acquisition additional advantage applied artifacts assess biopsy blocks body brain bulk cancer cartilage cause cells central centric characterization chosen clinical coil coils combined commonly composite conditions configured contents death decay degradation degree describes desensitize detected determining developed diagnosed diagnosis diffusion discrepancy displayed efficacy elevated employed enrolled exactly fast feasible fibrosis field frame function granular healthy hemorrhage heterogeneities human hypo illustrated improve in vivo indicate inhomogeneities inhomogeneity institute intensity interactions involvement kidney knee leading lesion liver location locking longer longitudinal macromolecular malignancy maps matrix metabolism metastatic middle minimize modified morphologic motion myocardial patient patients peripheral physiologic potentially preparation presence previous previously prostate protons pulses quantification quantitative radiation radiology reduce reflect refocusing remarkable reordering repetitions reported resolution robust rotational scanner sensitivity seven slice slow specifically spin spine staging stroke structure studies subject subjects successfully suggest suspected symmetric tissue transmit trio tumor tumors typical uniformity usually utilization variations varied various volunteers water zero zone