Meeting Banner
Abstract #0498

Cortical Oxygen Extraction as a Marker of Disease Stage & Function in Multiple Sclerosis: A Quantitative Study Using 7 Tesla MRI Susceptibility.

SUMMA25Audrey P. Fan1, 2, Revere P. Kinkel3, 4, Nancy K. Madigan3, 4, A Scott Nielson3, Thomas Benner2, Emanuele Tinelli5, Bruce R. Rosen2, 4, Elfar Adalsteinsson1, 2, Caterina Mainero2, 4

1Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, United States; 2Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States; 3Beth Israel Deaconess Medical Center, Boston, MA, United States; 4Harvard Medical School, Boston, MA, United States; 5Neurology and Psychiatry, University of Rome "La Sapienza", Rome, Italy

This study directly quantified OEF in individual cortical veins from patients at different stages of multiple sclerosis (MS) disease using MRI magnetic susceptibility measurements at 7 Tesla. Patients with late disease exhibited 6.2% absolute reduction in OEF compared to controls (p=0.024). Cortical OEF negatively correlated with disease duration (p=0.02) and white matter lesion volume (p<0.01). Across all patients, decreased OEF strongly associated with reduced cognitive performance, and cortical OEF was the main independent predictor of processing speed (p=0.03, stepwise regression). This study implicates metabolic deficiency early in the development of cognitive dysfunction in MS, and highlights OEF as a useful new metric of cortical pathology.

Abstract PDF Presentation Video

Keywords

ability absolute advantage allowing arising axial background beth biomedical brain channel characterization characterizes clinically closely cognitive cognitively coil computed control controls cortex cortical counts damage decrease decreased deep deficiency determined determining directly disability disease distinct duration dysfunction earlier early electrical executive extraction field filtered flash flow formation forward function greater healthy highlighting highlights house identified impaired implicates individual inflammatory initial insights investigate late learning least lesion lesions linear local location long magnitude manually marker matrix measures medical metabolic millimeter neurology originates oxygen parallel particularly pathological patient patients performance phenotypes physical plays predictor process processing progresses progressive psychiatry quantification quantitative recall recruited reduced reduction regression relapsing related relatively remitting resolution revere role sample scanned school science sclerosis scores secondary sensitive significantly speed spoiled stage stages status stepwise strictly strongly structural subjects surrounding susceptibility syndrome take technology thank tilt tissue type ultra underwent useful vein veins venous vessel views volume whether white years