Meeting Banner
Abstract #0491

Multimodal Validation of Oxidative Stress as a Pathophysiological Model of Chronic Fatigue Syndrome

Dikoma C. Shungu1, Nora Weiduscat1, James W. Murrough2, Xiangling Mao1, Sarah Pillemer2, Marvin S. Meddow3, Jonathan P. Dyke1, Benjamin H. Natelson4, Julian M. Stewart3, Sanjay J. Mathew5

1Radiology, Weill Cornell Medical College, New York, United States; 2Psychiatry, Mount Sinai School of Medicine; 3New York Medical College; 4Beth Israel Medical Center; 5Baylor College of Medicine

This study used multiple MR methods, including MRS measurement of the major antioxidant glutathione (GSH), to test the hypothesis that oxidative stress plays a major role in the pathophysiology of chronic fatigue syndrome (CFS).

Keywords

addition aimed among analyses anterior antioxidant anxiety beth blood brain capacity cerebral chronic cohort college common compelling complex conduct consistent content continuous control controls corrected correlate correlation cortex cortical criteria cross damage decrease decreased deficit depressive derived detection differed disorder disorders document documented documenting dress dysfunction editing elevated elevations emerging energy explain expressed extensive fatigue feature finding flow fluid free global health healthy hypotheses illness in vivo included independent institutional inversely investigate lactate lead lobe location major measure measured mechanistic medical medicine metabolites might model normalization normalized objectives observations occipital often overlap oxidant oxidative pall parametric participants patients phosphates poorly post postulated postulates potentially precursors presence previous prior psychiatry rationale reductions regional replicate replication reported reports reserves role school secondary sectional served shed significance significantly software spin statistical strategies stress studies subjects suggesting supporting supports sustained syndrome system targeted third toward towards treatment trend uncorrected understanding understood validity ventricular version weak whether whose