An Enzyme-Responsive PARACEST MRI Contrast Agent That "Turns On" After Catalysis

Keywords

accumulation acid activities activity adding agent agents although amide amides appearance applied arise biochemistry bond broad buffer catalysis caused chains chelated chelation chem chemistry cleavage close confirmed consistent consisting construct contrast coupling covalent covalently creation cross designed detect detects disappearance enzyme equivalents evaluated evidence excess experience extracellular final form forming frequencies good gradient heights hours important increments incubated indicate interact intermediates lacks least link lysine magnitude magnitudes mark mass matrix measure measuring media microbial minute mixture monitoring must nonspecific normalization paramagnetic peak peaks peptide plus possibly power precipitate press prior probability product products protecting proteins proximity pulse raising reactants reaction real recombinant removed responsive retention reverse sample saturation series side solvent spanning specificity spectra spectrometry spectroscopy spectrum strong studies subsequent supporting synthesis tissue tumor turns units unlike validated validates vascular water weak