MR Imaging of U87δEGFR Human Glioma Tumor Xenografts Using Targeted Signal-Amplifying Enzymatic System

Keywords

absence accumulation active administration agent amplification amplifying anesthesia animal animals anti antibody anticipated arrows assay attributed axial bearing best bimodal binding biology bound brain brains cancer capped cell cells characterized chem cold complementing conjugate conjugated conjugates consistent constant constants constitutively contrast culture days decay dependent described determinant determined displayed enabling enhancement enzymatic enzyme equation excess exclusion exhibit expression fitting form formation fragments generated glucose growth horseradish hours human humanized implantation implanted in vivo indicate indicating inhibited initial injected injection intensity internalization internalized labeled least linked localization long longer major matched matrix mediated medical minutes mixture modeled models molecular monoclonal much occasions optimal optimized orientations pair paramagnetic period peroxidase polymerized poor position presence previously products prognosis prolonged purified quantified radiology rats reaction receptor remained reported retained retention sacrificed school sections self sequential short significantly similarity sites specificity spin stained studies substrate surface synthesized system table target targeted temporal tumor tumors uptake vitro washout whereas