Meeting Banner
Abstract #0452

Mean Intracellular Water Molecule Lifetime: Another Useful Breast DCE-MRI Biomarker?

Wei Huang1, Xin Li1, Luminita A. Tudorica1, Karen Y. Oh1, Sunitha B. Thakur2, Elizabeth A. Morris2, Yiyi Chen1, Nicole Roy1, Mark D. Kettler1, Jason A. Koutcher2, Charles S. Springer1

1Oregon Health & Science University, Portland, OR, United States; 2Memorial Sloan Kettering Cancer Center, New York, United States

157 patients with 172 suspicious breast lesions underwent research DCE-MRI prior to biopsies. DCE-MRI time-course data were subjected to both Standard model (SM) and Shutter-Speed Model (SSM) analyses. Though not a good diagnostic biomarker, the mean intracellular water molecule lifetime, i, derived only with the SSM, was significantly smaller in malignant compared to benign lesions. i was also inversely correlated with SM and SSM Ktrans. The inverse relationships of i with cellular metabolic activity and Ktrans indicate its potential use for detection of hypoxia/necrosis and evaluation of breast cancer response to therapy.

Keywords

accounts accuracies accuracy acquisition acquisitions active activity additional allowed always analyses array assess assumes benign bilateral biopsies biopsy bolus breast cancer care cell characteristic clinical cohorts coils color compartmental conditions consented consistent constant correlated correlation counterparts course curve described detection diagnoses diagnostic displacement either entire evaluate evaluation exchange explored fact fast fitting former fraction gadolinium generally greater includes indicate indicating infinitely injection institution inter intra intracellular inverse inversely kinetics larger lesion lesions lifetime linear lists malignant maps markers measures membrane memorial metabolic metabolically metabolism model molecule negative occurred often operating panel parametric pathology patients perfect pixel poor population prediction previous prior procedures recalled receive recent referred reflected regime regression relationships remain resolution response sensitive sharing shutter significantly since slope smaller space spatial spots springer statistically studies subjected substantial substantially suggests suspicious systems temporal therapeutic therapy thick third tumor tumors twist underestimation uniform unilateral useful variable variance vein versa version vice water