Meeting Banner
Abstract #0451

3D Mapping of Total Choline in Human Breast Cancer Using High-Speed MR Spectroscopic Imaging at 3T: Initial Experience During Neoadjuvant Therapy

Stefan Posse1, 2, Tongsheng Zhang1, Melanie Royce3, Zoneddy Dayao3, Susan Lopez4, Laurel Sillerud5, Stephen Eberhardt6, Lesley Lomo7, Sang-Joon Lee8, Ashwani Rajput9, John Russell9, Linda Casey10, Patrick Bolan11

1Neurology, University of New Mexico, Albuquerque, NM, United States; 2Electrical and Computer Engineering, Physics and Astronomy, University of New Mexico, Albuquerque, NM, United States; 3Medical Oncology, University of New Mexico, Albuquerque, NM, United States; 4Clinical Trials Office, University of New Mexico, Albuquerque, NM, United States; 5Biochemistry, University of New Mexico, Albuquerque, NM, United States; 6Radiology, University of New Mexico, Albuquerque, NM, United States; 7Pathology, University of New Mexico, Albuquerque, NM, United States; 8Internal Medicine, University of New Mexico, Albuquerque, NM, United States; 9Surgery, University of New Mexico, Albuquerque, NM, United States; 10New Mexico Cancer Center, Albuquerque, NM, United States; 11Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States

Eleven patients with biopsy-confirmed, infiltrating ductal carcinoma were studied at 3T using 3D lipid suppressed Proton-Echo-Planar-Spectroscopic-Imaging (PEPSI) with a 10 min scan protocol and 1 cc voxel size. Strongly elevated tCho with mean concentrations between 0.3 and 4.1 mmol/kg was measured in 8 of the 11 patients with single and multi-centric enhancing lesions. Decreases in tCho concentration and number of voxels with detectable tCho were measured in 3 patients who underwent neoadjuvant therapy. An increase was measured in one patient. At TE 60 ms an additional resonance was detected that was elevated in enhancing lesions and tentatively assigned to Taurine.

Abstract PDF Presentation Video

Keywords

acceptable account acknowledge acquisition additional artifacts assessing averaging basis biochemistry biologic biopsy bound breast broad broadening cancer carcinoma centric channel characterization chemotherapy choline clinical coil collected compilation complete concentration confirmed consent constraints contamination correction coupled customized days decreases default described detectable detected detecting detection developed distorted elevated eleven empirically employed enhance enhancing entire equipped evaluation experience failure feasibility fitting focal frequency funding goals grade gradient heterogeneity improving infiltrating informed initial initiation instability intermediate invasive irregular john lesion lesions limitation lipid localized long major mapped mapping measured minutes monitoring motion navigator oblique office pathology patient patients peaks physics planar posse press previous progress protocol proton quantification radiology readout reconstructed related reliability report reported residual response risk saturates scanner selection sensitivity shapes smith soft south specificity spectral spectroscopic spectrum speed steps strongly studied studies suppression surgery table tailored technical tentatively term therapy threshold tissue treatment trials tumor undergoing underwent volume water width women