Meeting Banner
Abstract #0345

What Is Tissue Microstructure & Why Might We Want to Measure It?

John C. Gore1

1Vanderbilt University, Nashville, TN, United States

Conventional MRI measures the average macroscopic properties of tissue water hydrogen nuclei from small, spatially-resolved voxels and is not well suited to provide specific information about tissue molecular composition. However, a variety of approaches have been developed that allow information to be obtained about the heterogeneity of tissue properties from within voxels, along with information on their micro-anatomy on scales much below voxel dimensions, permitting the derivation of parameters that can be used for quantitative tissue characterization. These methods have found applications in several tissues including nerve, tumor, muscle and bone.

Keywords

able accurately acquisition allow anatomic anisotropy applications approaches appropriate arrangements assumes available bone cell cells characterization chemical clearly combine component composition contain contains contrast crude decreasing defined defy derivation derived descriptors detailed determined developed diffusion dimensions even examples exchange features finer free glance gore heterogeneity hindrances hundreds hybrid identify include incorporate individual insights institute interactions interpretation introduces john linear lipid localization macroscopic magnetization mainly measure micro microns might millions mobile models molecular molecules much muscle need nerve noise novel occur pathological permitting populations portray practice precise processes produces properties protein proton protons quantitative relatively resolution resolving restrictions reveal sample scale scales science self sensitized several spatial spectral spectroscopy statistical structure subtle sugar suited thousands tissue tissues transfer tumor typically variations variety volume want water whereas whose