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Abstract #0344

Combined Diffusion-Weighted-, Blood Oxygen Level Dependent- And Dynamic Contrast Enhanced-MRI for Assessment of Renal Cell Carcinoma.

Mike Notohamiprodjo1, Michael Staehler2, Nicole Steiner1, Felix Schwab3, Steven P. Sourbron4, Henrik J. Michaely5, Maximilian F. Reiser1, Konstantin Nikolaou1

1Department of Clinical Radiology, University Hospitals Munich, Munich, Bavaria, Germany; 2Clinic for Urology, University Hospitals Munich; 3Department of Clinical Radiology, Josef Lissner Institute for Biomedical Imaging, University Hospitals Munich, Munich, Bavaria, Germany; 4Medical Physics, University of Leeds; 5Department of Clinical Radiology and Nuclear Medicine, University Hospital Mannheim

Multiple MR-techniques for functional tumor evaluation are available, however correlation of these techniques has not been investigated. A protocol comprising Diffusion weighted Imaging (DWI), Blood oxygen level dependent (BOLD) and Dynamic contrast enhanced (DCE)-MRI is feasible for assessment of primary RCC. BOLD moderately correlates to perfusion derived from DCE-MRI. ADC shows moderate correlation to the extracellular volume, but does not correlate to tumor oxygenation or perfusion as it provides mixed information on both perfusion and cellularity. IVIM analysis may resolve this ambiguity. Tumor permeability does not correlate to any other functional parameter.

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Keywords

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