Meeting Banner
Abstract #0341

Longitudinal Measurement of Renal Oxygenation & Perfusion in Donor-Recipient Pairs Using BOLD & ASL MRI

MAGNA25David J. Niles1, Nathan S. Artz1, Elizabeth A. Sadowski2, Arjang Djamali3, Thomas M. Grist1, 2, Sean B. Fain1, 2

1Medical Physics, University of Wisconsin, Madison, WI, United States; 2Radiology, University of Wisconsin, Madison, WI, United States; 3Medicine, University of Wisconsin, Madison, WI, United States

Routine monitoring of renal function following transplantation is important for early detection of disease. In this study we used BOLD and ASL MRI to measure renal oxygenation and perfusion, respectively, in matched pairs of kidney transplant donors and recipients up to two years following transplantation. Statistically significant decreases in cortical perfusion and medullary oxygenation were observed in transplanted kidneys 3 months post-transplantation and remained present one year post-transplantation. Further measurements in this ongoing study will be used to statistically assess function two years post-transplantation.

Abstract PDF Presentation Video

Keywords

acknowledgments although approved array arterial assess assumed asterisks availability available blood blue bold breath cardiac channel chronic coaching coil collection commonly compartment compliant consisted consumption continued control coronal correspond cortex cortical currently decaying decline decreased denote dependent detection disease donor donors drawn early echoes electric error evaluate evaluated examine exams explained explanation exponential fain fair fitting function functional general generated grateful green grist human implying important included indicating inhibitors injury interactive inversion kidney labeling lacking late long longitudinal maps materials medical medicine medulla metabolism might model monitoring months mutual normalized ongoing oxygen oxygenation pairs paradoxical parametric part perfusion persistent physics poor post prescribed prior processes processing protocol radiology rank recalled recipient recipients registered relatively remained remaining renal respectively respiratory routine scanner segmented sensitive sensitivity serum signed significantly slice slices spin statistical statistically studies subjects submission support surgery term thresholding tissue transplant transplantation transplanted triggering tubular typical unclear vessels year years yellow