Meeting Banner
Abstract #0199

In Vivo Imaging of Vessel Diameter, Size & Density: A Comparative Study between MRI & Histology

Benjamin Lemasson1, 2, Samuel Valable1, 3, Rgine Farion1, 2, Alexandre Krainik1, 2, Chantal Rmy1, 2, Emmanuel L. Barbier1, 2

1U836, Inserm, Grenoble, France; 2Grenoble Institut des Neurosciences, Universit Joseph Fourier, Grenoble, France; 3UMR 6232, CNRS, Caen, France

The purpose of the study was to compare MRI and histological estimates of the mean vessel diameter (mVD), the vessel density (Density), and the vessel size index (VSI) obtained in the same tumor-bearing animals (C6 and RG2 models). MRI and histology differed by -15 to 26%. A positive correlation was found between MRI and histology for mVD, Density, and VSI counterparts (R=0.62, 0.50, 0.73, respectively; p<0.001 in all cases). As Density and mVD or VSI provide complementary information, it is worth computing them to characterize angiogenesis beyond blood volume fraction.

Keywords

adjacent administration advanced agent agreement analyzed animal animals apparent appears approaches assessment bearing becomes best better beyond blind blood body bolus brain brains characteristics characterization characterize chelate closest coefficient collagen combination comparative complementary compute computed computing constant containing contrast contributes correlated correlation corresponded days decrease defined delineate delineated density derived described description desirable determining diameter diameters diffusion digitization distribution drawn dynamic early echoes either evenly experiment field fraction frozen give good grade gradient hand histological histology horizontal immediately implantation improve in vivo index indicates induced injection introduced iron just largest latter liquid lowest male maps measured measuring microscopic model models modified moles morphological mouse neocortex nitrogen noted object patients pooled positive previously prior processes processing prognosis proposed quantitative quickly rats recently remain removed reported respectively section sections slice sliced snap spaced spin stained steady stored stroke structures studied tail thick tracking transverse tumor usually vascular vein vessel view views volume water worth yielded