Meeting Banner
Abstract #0160

Simultaneous Acquisition of Quantitative ASL & T2* (SQUAB) for Characterization of Skeletal Muscle Hemodynamics.

Ronn P. Walvick1, Ruth P. Lim1, Vivian S. Lee2

1Radiology, New York University Langone Medical Center, New York, NY, United States; 2The University of Utah, Salt Lake City, UT, United States

BOLD and perfusion change rapidly in skeletal muscle following exercise. In this work, we propose a sequence that allows for simultaneous quantification of T2* and ASL using a sequence featuring dual-echo EPI readouts, and saturation prepared FAIR prepulses for blood labeling. This sequence was tested in a cohort of volunteers and a patient with peripheral arterial disease. We show considerable increases in T2*and blood flow from baseline following exercise in volunteers and a blunted, delayed patient response. Our results show the feasibility of quickly acquiring simultaneous blood flow and T2* data and demonstrate sensitivity to disease

Abstract PDF Presentation Video

Keywords

accomplished accuracy acquisition allow alternating ankle anterior applied arterial band bilateral bilaterally block blocks blood bold boss calf city coil commenced conducted consisting consists contains correct demonstrating design determine ding disease dynamically efficacy either elastic evaluation excitation exercise exercised exhaustion fair feasibility finally find flow foot function future gradient hyperemia implemented include included initial intensities inversion knee labeling larger long magnetization male maps matrix maximally measured metabolism minim minimizes minutes monitor muscle next observable offers partial patient perfusion period peripheral placing plantar population post potential preceded preparation prepared previous prior protocol pulse pulses quantitative quiring radiology rapidly reached readouts recovery remained repetition required resistance resolution respectively response responses rest rested restricted salt saturation schemes secant selective several simultaneous sing skeletal slice slightly spin spoiling squab subjects subtracting system temp third tissue train unchanged undetectable volunteers water wing year