Meeting Banner
Abstract #0139

Super-Resolution Track-Weighted Functional Connectivity (TW-FC): A Tool for Characterizing the Structural-Functional Connections in the Brain

Fernando Calamante1, 2, Richard Andrew James Masterton1, Jacques-Donald Tournier1, 2, Robert Elton Smith1, 2, Lisa Willats1, David Raffelt1, Alan Connelly1, 2

1Brain Research Institute, Florey Neuroscience Institutes, Heidelberg, Victoria, Australia; 2Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia

We apply the recently proposed super-resolution track-weighted imaging (TWI) methodology, to combine whole-brain fibre-tracking data (the so-called tractogram) with resting state functional connectivity (FC) data, to generate track-weighted (TW) FC maps of a given FC network. The method was assessed on data from 8 healthy volunteers. The TW-FC technique provides an approach for the fusion of structural and functional data into a single quantitative image. A potential important application of this methodology is for quantitative voxel-wise group comparison.

Keywords

affect anatomical applied assigned axial back band bottom brain bundles called carried combine combined combining computed concatenated connecting connections connectivity consistent coordinate coronal corpus corrected correction correlation corresponds cortex course dataset deconvolution default degree density describes description detail diffusion directly display displayed distortions done editing element example examples exploits extend extended extent fiber filtered findings fluctuations frontal functional fusion generate generated generating grid healthy honey house identified illustrates illustration important includes individual inferior institutes intensity intrinsic introduced isotropic maps maximal medial methodology million model motion native naturally network networks normalized occipital opposite ordinate overall pass pathway pathways posterior potential powerful previous principles probabilistic proposed quantitative radius recent recently reflects regressed represented resolution role scanner seed seeded sensitivity similarly since slow smith smoothed software space spherical spontaneous streamlines structural structures studies subject subset super superior susceptibility template temporal thresholded tool track tracking tracks transformed traversing twice typical version volumes volunteers white whole