Overcoming the Low Relaxivity of Gadofosveset at High Field with Spin Locking

Keywords

account achieved addition additional affinity agent agents albumin alone although applied around assessing award axis bars binding binds bound bovine buffered characteristics chem circles clinical combination combining commonly comparable concentrations confidence conjunction consider constant containing contrast convergence crosses decrease determine determined displaying distinct division duration durations eight equivalent error excitation exponential facilitates feasibility field fields frame free fully funding gadolinium generate give heating human hypothesized impact implementation improved in vivo industrial influence influenced intensity interaction intervals invest investigation john kingdom larger leading likely literature little locking longitudinal macromolecular macromolecules marketed measured medical moderate modification molecule mono much muller necessary nonlinear noted novel opportunity optimal overcoming peaks pharmaceuticals phosphate physics physiological potential presence previously prior properties published pulse radiology rare rather readout recovered recovery repetition represent representing require rotating saline saturation search sensitivity separate serum setting significantly slightly solutions spin spins squares strength strengths studies substantial suggest tanner tenfold tissue trisodium unbound vitro west