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Abstract #0107

Combined Dual Frequency 19F and 1H MRI in the Human Digestive Tract

Tobias Hahn1, Ruben Pellicer Guridi1, 2, Werner Schwizer3, Sebastian Kozerke1, Michael Fried3, Peter Boesiger1, Andreas Steingoetter1, 3

1Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland; 2Department of Biophysics and Bioengineering, University of Barcelona, Barcelona, Spain; 3Dep. of Internal Medicine, Division of Gastroenterology and Hepatology, Zurich, Switzerland

This study presents the 3D tracking of fluorine labeled capsules through the human intestinal tract using a dual frequency excitation scheme with a temporal resolution of 255ms. Liquid fluorine markers were Hexafluorobenzene and Perfluoro-15-crown-5-ether and capsule filling was 65l each. The study was performed in five healthy volunteers on two study days. Initial results are shown regarding the temporal and structural behavior of the capsule passages through the digestive tract.

Keywords

abdominal administered agent agents always anatomic assignment automatically averaging balanced bandwidth best bioengineering biomedical biophysics body breathing capsule capsules channel chem coil combined compound compounds computed conformity consisted constant containing coordinate coordinates correlation criteria cross crown days delivery dependence described design detected determined diameter differently digestive distance division drug dual dynamic either engineering enough errors ether excitation exogenously expected fast feasibility filter filtered finding fitting freedom frequencies frequency fried functional geometries geometry global good human immediately in vivo induced ingested institute interleaved internal interpolation intestinal intestines introduced labeled lateral lead local loops marker markers materials might mode modified optimized parametric passage peak periods polynomial profiles projection projections proposed pulse pulses quadrature receive recently reconstructed reduce referencing regard registration relatively reliable resolution respectively selection shimming since slightly smearing space spatial spectral springer stomach strong studies subjects surface survey surveys synchronously system temporal tracking tract trajectory transmit unambiguous unique unwanted variance velocity visualized volunteer whole